immunologic tolerance【免疫】 - PMC

Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. Spicer, Nirupama D. Verma, Suzanne J. Hodgkinson, Bruce M. Hall

Front Immunol. 2022; 13: 1017683. Published online 2022 Nov 8. doi: 10.3389/fimmu.2022.1017683

PMCID:: PMC9681496

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A composite score associated with spontaneous operational tolerance in kidney transplant recipients

Richard Danger, Mélanie Chesneau, Chloé Paul, Pierrick Guérif, Maxim Durand, Kenneth A Newell, Sai Kanaparthi, Laurence A Turka, Jean-Paul Soulillou, Rémi Houlgatte, Magali Giral, Gérard Ramstein, Sophie Brouard

Kidney Int. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Kidney Int. 2017 Jun; 91(6): 1473–1481. Published online 2017 Feb 24. doi: 10.1016/j.kint.2016.12.020

PMCID:: PMC5432017

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Biomarkers of Operational Tolerance Following Kidney Transplantation – The Immune Tolerance Network Studies of Spontaneously Tolerant Kidney Transplant Recipients

Kenneth A. Newell, Andrew B. Adams, Laurence A. Turka

Hum Immunol. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Hum Immunol. 2018 May; 79(5): 380–387. Published online 2018 Feb 12. doi: 10.1016/j.humimm.2018.02.007

PMCID:: PMC5924709

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Immunological Consequences of In Utero Exposure to Foreign Antigens

Jeng-Chang Chen

Front Immunol. 2021; 12: 638435. Published online 2021 Apr 15. doi: 10.3389/fimmu.2021.638435

PMCID:: PMC8082100

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Immune Interventions to Preserve Beta Cell Function in Type 1 Diabetes

Mario R. Ehlers

J Investig Med. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: J Investig Med. 2016 Jan; 64(1): 7–13. doi: 10.1097/JIM.0000000000000227

PMCID:: PMC4732932

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Biomarkers and mechanisms of tolerance induction in food allergic patients drive new therapeutic approaches

Carolyn H. Baloh, Michelle F. Huffaker, Tanya Laidlaw

Front Immunol. 2022; 13: 972103. Published online 2022 Oct 3. doi: 10.3389/fimmu.2022.972103

PMCID:: PMC9574092

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Establishment of Chimerism and Organ Transplant Tolerance in Laboratory Animals: Safety and Efficacy of Adaptation to Humans

Robert Lowsky, Samuel Strober

Front Immunol. 2022; 13: 805177. Published online 2022 Feb 10. doi: 10.3389/fimmu.2022.805177

PMCID:: PMC8866443

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Advances in dendritic cell targeting nano-delivery systems for induction of immune tolerance

Guojiao Lin, Jialiang Wang, Yong-Guang Yang, Yuning Zhang, Tianmeng Sun

Front Bioeng Biotechnol. 2023; 11: 1242126. Published online 2023 Oct 9. doi: 10.3389/fbioe.2023.1242126

PMCID:: PMC10593475

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Induction of Immune Tolerance to Foreign Protein via Adeno-Associated Viral Vector Gene Transfer in Mid-Gestation Fetal Sheep

Marcus G. Davey, John S. Riley, Abigail Andrews, Alec Tyminski, Maria Limberis, Jennifer E. Pogoriler, Emily Partridge, Aliza Olive, Holly L. Hedrick, Alan W. Flake, William H. Peranteau

PLoS One. 2017; 12(1): e0171132. Published online 2017 Jan 31. doi: 10.1371/journal.pone.0171132

PMCID:: PMC5283730

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Immune Tolerance Therapy: A New Method for Treatment of Traumatic Brain Injury

Ruo-Yang Feng, Qian Chen, Wei-Jian Yang, Xiao-Guang Tong, Zhi-Ming Sun, Hua Yan

Chin Med J (Engl) 2018 Aug 20; 131(16): 1990–1998. doi: 10.4103/0366-6999.238147

PMCID:: PMC6085845

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Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications

Jin-Yu Sun, Rui Wu, Jiang Xu, Hui-Ying Xue, Xiao-Jie Lu, Jiansong Ji

Front Immunol. 2021; 12: 705950. Published online 2021 Aug 3. doi: 10.3389/fimmu.2021.705950

PMCID:: PMC8370472

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Efficacy and Safety of Oral Immunotherapy in a Randomized, Placebo-Controlled Study of 1–3-Year Old Children with Peanut Allergy: Findings from the Immune Tolerance Network IMPACT Trial

ITN050AD IMPACT Study Team

Lancet. Author manuscript; available in PMC 2023 Jan 22.

Published in final edited form as: Lancet. 2022 Jan 22; 399(10322): 359–371. doi: 10.1016/S0140-6736(21)02390-4

PMCID:: PMC9119642

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A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3⁺ T regulatory cells

Hideto Matsui, Masaru Shibata, Brian Brown, Andrea Labelle, Carol Hegadorn, Chandler Andrews, Marinee Chuah, Thierry VandenDriessche, Carol H. Miao, Christine Hough, David Lillicrap

Blood. 2009 Jul 16; 114(3): 677–685. Published online 2020 Nov 28. doi: 10.1182/blood-2009-03-202267

PMCID:: PMC9710235

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Restoring the balance: immunotherapeutic combinations for autoimmune disease

Dawn E. Smilek, Mario R. Ehlers, Gerald T. Nepom

Dis Model Mech. 2014 May; 7(5): 503–513. doi: 10.1242/dmm.015099

PMCID:: PMC4007402

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PMC Images search for immunologic tolerance【免疫】

Fig. 7Mechanisms of PD-1-mediated T-cell tolerance

PD-L1 ligation of PD-1 following TCR stimulation results in two possible T-cell fates: diminished T-effector responses and augmented iTreg development, thus tipping the balance towards immunologic tolerance.

The PD-1 Pathway in Tolerance and Autoimmunity

Immunol Rev. ;236:219-242.
Figure 1

Immunologic tolerance and autoimmune diseases. An illustration showing the normal intrinsic and extrinsic mechanisms of immunologic tolerance. Loss of tolerance results in inappropriate production of autoantibodies and in autoimmune diseases.

Autoantibodies and Cardiac Arrhythmias

Heart Rhythm. ;8(11):10.1016/j.hrthm.2011.06.032.
Figure 4

Flow chart comparing the basic func;ons of mature versus immature dendri;c cells and their contribu;ons to immunologic s;mula;on versus tolerance. (DC, dendri;c cell)

State of the Art: Role of the Dendritic Cell in Induction of Allograft Tolerance

Transplantation. ;102(10):1603-1613.
Figure 4:Peripheral and barrier tolerance mechanisms.

(A) Peripheral tolerance of autoreactive effector T cells is maintained via inhibition by thymic Tregs, induction of anergy, antigenic ignorance, or differentiation to inducible Tregs. (B) The intact islet ECM provides physical and immunologic barriers (“barrier tolerance”) that contribute to immune tolerance. These include a basement membrane that prevents immune infiltration, protective barriers against reactive oxygen species as with HS, and immunomodulatory barriers like the stabilization and sequestration of HA that limit immune activation.

Extracellular Matrix and the Maintenance and Loss of Peripheral Immune Tolerance in Autoimmune Insulitis

Curr Opin Immunol. ;55:22-30.